Harmonized Data (TOPMed DCC Harmonized Clinical Variables)

There are limited amounts of harmonized data available at this time. The TOPMed Data Coordinating Center (DCC) curation team has identified 78 variables that are shared across several NHLBI studies and normalized the participant values for these variables.

The harmonized variables are listed in the table in Appendix 2. For more information on this initiative, you can view the additional documentation from the TOPMed DCC GitHub repository or on the NHLBI Trans-Omics for Precision Medicine website.

The dcc_harmonization_comments field in the TOPMed DCC GitHub repository helps to provide more context to the variables.

For example, the "Body mass index" variable in the TOPMed DCC Harmonized Dataset has a highly implausible maximum value of 348. The dcc_harmonization_comments field of the BMI code explains that the BAGS study had unlikely height and weight measurements for six participants.

Table of Studies Included in the TOPMed Harmonized Dataset Available in BDC-PIC-SURE

Study Name	Abbreviation	Accession Number
Diabetes Heart Study (DHS) African American Coronary Artery Calcification (AACAC)	AACAC	phs001412
Genetics of Cardiometabolic Health in Amish	AMISH	phs000956
Atherosclerosis Risk in Communities Study	ARIC	phs000280*
The Genetics and Epidemiology of Asthma in Barbados	BAGS	phs001143
Coronary Artery Risk Development in Young Adults Study	CARDIA	phs000285*
Cleveland Clinic Atrial Fibrillation Study	CCAF	phs001189
Cleveland Family Study	CFS	phs000284
Cardiovascular Health Study	CHS	phs000287
Genetic Epidemiology of COPD	COPDGene	phs000179
Epidemiology of Asthma in Costa Rica Study	CRA	phs000988
Framingham Heart Study	FHS	phs000007
Genes-Environments and Admixture in Latino Asthmatics (GALA II) Study	GALAII	phs001180
Genetic Study of Atherosclerosis Risk	GeneSTAR	phs001218
Genetic Epidemiology Network of Arteriopathy	GENOA	phs001238
Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Lipidomics Study	GOLDN	phs000741 (Available in PIC-SURE via phs001359)
Hispanic Community Health Study - Study of Latinos	HCHS-SOL	phs000810
Heart and Vascular Health Study	HVH	phs001013
Jackson Heart Study	JHS	phs000286*
Whole Genome Sequencing of Venous Thromboembolism (WGS of WTE)	MAYOVTE_Olmsted	phs001402
Multi-Ethnic Study of Atherosclerosis	MESA	phs000209
Massachusetts General Hospital Atrial Fibrillation Study	MGHAF	phs001001
Partners HealthCare Biobank	PARTNERS	phs001024
Study of African Americans, Asthma, Genes, and Environments Study	SAGE	phs000921
Study of Adiposity in Samoans	SAS	phs000914
Vanderbilt AF Ablation Registry	VAFAR	phs000997
The Vanderbilt Atrial Fibrillation Registry	VUAF	phs001032
Novel Risk Factors for the Development of Atrial Fibrillation in Women	WGHS	phs001040
Women's Health Initiative	WHI	phs000200

*Indicates study access temporarily suspended.