Appendix 2: Table of TOPMed DCC Harmonized Variables in PIC-SURE
angina_incident_1
An indicator of whether a subject had an angina event (that was verified by adjudication or by medical professionals) during the follow-up period.
encoded
0=Angina event did not occur during follow-up || 1=Angina event occurred during follow-up
angina_prior_1
An indicator of whether a subject had an angina event prior to the baseline visit.
encoded
0=Did not have a history of angina before baseline || 1=Had a history of angina before baseline
annotated_sex_1
Subject sex, as recorded by the study.
encoded
female=Female || male=Male
antihypertensive_meds_1
Indicator for use of antihypertensive medication at the time of blood pressure measurement.
encoded
0=Not taking antihypertensive medication || 1=Taking antihypertensive medication
basophil_ncnc_bld_1
Count by volume, or number concentration (ncnc), of basophils in the blood (bld).
decimal
thousands / microliter
bmi_baseline_1
Body mass index calculated at baseline.
decimal
kg/m^2
bp_diastolic_1
Resting diastolic blood pressure from the upper arm in a clinical setting.
decimal
mmHg
bp_systolic_1
Resting systolic blood pressure from the upper arm in a clinical setting.
decimal
mmHg
cabg_incident_1
An indicator of whether a subject had a coronary artery bypass graft (CABG) procedure (that was verified by adjudication or by medical professionals) during the follow-up period.
encoded
0=CABG procedure did not occur during follow-up || 1=CABG procedure occurred during follow-up
cabg_prior_1
An indicator of whether a subject had a coronary artery bypass graft (CABG) procedure prior to the start of the baseline visit.
encoded
0=Did not have a CABG procedure before baseline || 1=Had a CABG procedure before baseline
cac_score_1
Coronary artery calcification (CAC) score using Agatston scoring of CT scan(s) of coronary arteries
decimal
cac_volume_1
Coronary artery calcium volume using CT scan(s) of coronary arteries
decimal
cubic millimeters
cad_followup_start_age_1
Age of subject at the start of the follow-up period during which atherosclerosis events were reviewed and adjudicated.
decimal
cad_followup_start_age
carotid_plaque_1
Presence or absence of carotid plaque.
encoded
0=Plaque not present || 1=Plaque present
carotid_stenosis_1
Extent of narrowing of the carotid artery.
encoded
0=None || 1=1%-24% || 2=25%-49% || 3=50%-74% || 4=75%-99% || 5=100%
cd40_1
Cluster of differentiation 40 ligand (CD40) concentration in blood.
decimal
ng/mL
chd_death_definite_1
An indicator of whether the cause of death was determined by medical professionals or technicians to be "definite" coronary heart disease for subjects who died during the follow-up period.
encoded
0=Death did not occur during follow-up, or cause of CHD death was not determined as definite CHD || 1=CHD death occurred during follow-up and was determined as definite
chd_death_probable_1
An indicator of whether the cause of death was determined by medical professionals or technicians to be "probable" or "definite" coronary heart disease for subjects who died during the follow-up period.
encoded
0=Death did not occur during follow-up, or cause of CHD death was not determined as definite or probable CHD || 1=CHD death occurred during follow-up and was determined as probable or definite
cimt_1
Common carotid intima-media thickness, calculated as the mean of two values: mean of multiple thickness estimates from the left far wall and from the right far wall.
decimal
mm
cimt_2
Common carotid intima-media thickness, calculated as the mean of four values: maximum of multiple thickness estimates from the left far wall, left near wall, right far wall, and right near wall.
decimal
mm
coronary_angioplasty_incident_1
An indicator of whether a subject had a coronary angioplasty procedure (that was verified by adjudication or by medical professionals) during the follow-up period.
encoded
0=Coronary angioplasty procedure did not occur during follow-up || 1=Coronary angioplasty procedure occurred
during follow-up
coronary_angioplasty_prior_1
An indicator of whether a subject had a coronary angioplasty procedure prior to the start of the baseline visit.
encoded
0=Did not have a coronary angioplasty procedure before baseline || 1=Had a coronary angioplasty procedure before baseline
coronary_revacularization_prior_1
An indicator of whether a subject had a coronary revascularization procedure prior to the start of the baseline visit. This includes angioplasty, CABG, and other coronary revascularization procedures.
encoded
0=Did not have a coronary revascularization procedure before baseline || 1=Had a coronary revascularization procedure before baseline
current_smoker_baseline_1
Indicates whether subject currently smokes cigarettes.
encoded
0=Does not currently smoke cigarettes || 1=Currently smokes cigarettes
crp_1
C-reactive protein (CRP) concentration in blood.
decimal
mg/L
eosinophil_ncnc_bld_1
Count by volume, or number concentration (ncnc), of eosinophils in the blood (bld).
decimal
thousands / microliter
eselectin_1
E-selectin concentration in blood.
decimal
ng/mL
ever_smoker_baseline_1
Indicates whether subject ever regularly smoked cigarettes.
encoded
0=Never a cigarette smoker || 1=Current or former cigarette smoker
fasting_lipids_1
Indicates whether participant fasted for at least eight hours prior to blood draw to measure lipids phenotypes.
encoded
0=Participant did not fast_or fasted for fewer than eight hours prior to measurement of lipids phenotypes. || 1=Participant fasted for at least eight hours prior to measurement of lipids phenotypes
geographic_site_1
Recruitment/field center, baseline clinic, or geographic region.
encoded
hdl_1
Blood mass concentration of high-density lipoprotein cholesterol
decimal
mg/dL
height_baseline_1
Body height at baseline.
decimal
cm
hematocrit_vfr_bld_1
Measurement of hematocrit, the fraction of volume (vfr) of blood (bld) that is composed of red blood cells.
decimal
% = percentage
hemoglobin_mcnc_bld_1
Measurement of mass per volume, or mass concentration (mcnc), of hemoglobin in the blood (bld).
decimal
g / dL = grams per deciliter
hispanic_or_latino_1
Indicator of reported Hispanic or Latino ethnicity.
encoded
ethnicity component dbGaP variable values for a subject were inconsistent/contradictory (e.g. over multiple visits) || Hispanic or Latino || not Hispanic or Latino
hispanic_subgroup_1
classification of Hispanic/Latino background for Hispanic/Latino subjects where country or region of origin information is available
encoded
CentralAmerican=Central American || CostaRican=from Costa Rica || Cuban=Cuban || Dominican=Dominican || Mexican=Mexican || PuertoRican=Puerto Rican || SouthAmerican=South American
icam1_1
Intercellular adhesion molecule 1 (ICAM1) concentration in blood.
decimal
ng/mL
il1_beta_1
Interleukin 1 beta (IL1b) concentration in blood.
decimal
pg/mL
il10_1
Interleukin 10 (IL10) concentration in blood.
decimal
pg/mL
il18_1
Interleukin 18 (IL18) concentration in blood.
decimal
pg/mL
il6_1
Interleukin 6 (IL6) concentration in blood.
decimal
pg/mL
isoprostane_8_epi_pgf2a_1
Isoprostane 8-epi-prostaglandin F2 alpha (8-epi-PGF2a) concentration in urine.
decimal
pg/mL
ldl_1
Blood mass concentration of low-density lipoprotein cholesterol
decimal
mg/dL
lipid_lowering_medication_1
Indicates whether participant was taking any lipid-lowering medication at blood draw to measure lipids phenotypes
encoded
0=Participant was not taking lipid-lowering medication || 1=Participant was taking lipid-lowering medication
lppla2_act_1
Activity of lipoprotein-associated phospholipase A2 (LP-PLA2), also known as platelet-activating factor acetylhydrolase, measured in blood.
decimal
nmol/min/mL
lppla2_mass_1
Mass of lipoprotein-associated phospholipase A2 (LP-PLA2), also known as platelet-activating factor acetylhydrolase, measured in blood.
decimal
ng/mL
lymphocyte_ncnc_bld_1
Count by volume, or number concentration (ncnc), of lymphocytes in the blood (bld).
decimal
thousands / microliter
mi_incident_1
An indicator of whether a subject had a myocardial infarction (MI) event (that was verified by adjudication or by medical professionals) during the follow-up period.
encoded
0=MI event did not occur during follow-up || 1=MI event occurred during follow-up
mi_prior_1
An indicator of whether a subject had a myocardial infarction (MI) prior to the start of the baseline visit.
encoded
0=Did not have a history of MI before baseline || 1=Had a history of MI before baseline
mch_entmass_rbc_1
Measurement of the average mass (entmass) of hemoglobin per red blood cell(rbc), known as mean corpuscular hemoglobin (MCH).
decimal
pg = picogram
mchc_mcnc_rbc_1
Measurement of the mass concentration (mcnc) of hemoglobin in a given volume of packed red blood cells (rbc), known as mean corpuscular hemoglobin concentration (MCHC).
decimal
g /dL = grams per deciliter
mcp1_1
Monocyte chemoattractant protein-1 (MCP1), also known as C-C motif chemokine ligand 2, concentration in blood.
decimal
pg/mL
mmp9_1
Matrix metalloproteinase 9 (MMP9) concentration in blood.
decimal
ng/mL
mcv_entvol_rbc_1
Measurement of the average volume (entvol) of red blood cells (rbc), known as mean corpuscular volume (MCV).
decimal
fL = femtoliter
monocyte_ncnc_bld_1
Count by volume, or number concentration (ncnc), of monocytes in the blood (bld).
decimal
thousands / microliter
mpo_1
Myeloperoxidase (MPO) concentration in blood.
decimal
ng/mL
neutrophil_ncnc_bld_1
Count by volume, or number concentration (ncnc), of neutrophils in the blood (bld).
decimal
thousands / microliter
opg_1
Osteoprotegerin (OPG) concentration in blood.
decimal
pmol/L
pad_incident_1
An indicator of whether a subject had peripheral arterial disease (that was verified by adjudication or by medical professionals) during the follow-up period.
encoded
0=No diagnosis of PAD during follow-up || 1=PAD was diagnosed during follow-up
pad_prior_1
An indicator of whether a subject had peripheral arterial disease prior to the baseline visit.
encoded
0=Did not have a history of PAD before baseline || 1=Had a history of PAD before baseline
platelet_ncnc_bld_1
Count by volume, or number concentration (ncnc), of platelets in the blood (bld).
integer
thousands / microliter
pmv_entvol_bld_1
Measurement of the mean volume (entvol) of platelets in the blood (bld), known as mean platelet volume (MPV or PMV).
decimal
fL = femtoliter
pselectin_1
P-selectin concentration in blood.
decimal
ng/mL
race_us_1
Harmonized race category of participant.
encoded
AI_AN=American Indian_Alaskan Native or Native American || Asian=Asian || Black=Black or African American || HI_PI=Native Hawaiian or other Pacific Islander || Multiple=More than one race || Other=Other race || White=White or Caucasian
rbc_ncnc_bld_1
Count by volume, or number concentration (ncnc), of red blood cells in the blood (bld).
decimal
millions / microliter
rdw_ratio_rbc_1
Measurement of the ratio of variation in width to the mean width of the red blood cell (rbc) volume distribution curve taken at +/- 1 CV, known as red cell distribution width (RDW).
decimal
% = percentage
sleep_duration_1
Usual amount of time slept per day.
decimal
hours/day
subcohort_1
A distinct subgroup within a study, generally indicating subjects who share similar characteristics due to study design. Subjects may belong to only one subcohort.
encoded
tnfa_1
Tumor necrosis factor alpha (TNFa) concentration in blood.
decimal
pg/mL
tnfa_r1_1
Tumor necrosis factor alpha receptor 1 (TNFa-R1) concentration in blood.
decimal
pg/mL
tnfr2_1
Tumor necrosis factor receptor 2 (TNFR2) concentration in blood.
decimal
pg/mL
total_cholesterol_1
Blood mass concentration of total cholesterol
decimal
mg/dL
triglycerides_1
Blood mass concentration of triglycerides
decimal
mg/dL
vte_case_status_1
An indicator of whether a subject experienced a venous thromboembolism event (VTE) that was verified by adjudication or by medical professionals.
encoded
0=Not known to ever have a VTE event_either self-reported or from medical records || 1=Experienced a VTE event as verified by adjudication or by medical professionals
vte_followup_start_age_1
Age of subject at the start of the follow up period during which venous thromboembolism (VTE) events were reviewed and adjudicated.
decimal
years
vte_prior_history_1
An indicator of whether a subject had a venous thromboembolism (VTE) event prior to the start of the medical review process (including self-reported events).
encoded
0=did not have prior VTE event || 1=had prior VTE event
wbc_ncnc_bld_1
Count by volume, or number concentration (ncnc), of white blood cells in the blood (bld).
decimal
thousands / microliter
weight_baseline_1
Body weight at baseline.
decimal
kg
age_at_*
For each phenotypic value for a given subject, an associated age at measurement is provided.
decimal
years
unit_*
For each harmonized variable, a paired “unit_variable” is provided, whose value indicates where in the documentation to look to find the set of component variables and the algorithm used to harmonize those variables.
encoded
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