Appendix 2: Table of TOPMed DCC Harmonized Variables in PIC-SURE

Variable Name	Variable Description	TYPE	UNITS	VALUES
cac_volume_1	Coronary artery calcium volume using CT scan(s) of coronary arteries	decimal	cubic millimeters
cac_score_1	Coronary artery calcification (CAC) score using Agatston scoring of CT scan(s) of coronary arteries	decimal
cimt_1	Common carotid intima-media thickness, calculated as the mean of two values: mean of multiple thickness estimates from the left far wall and from the right far wall.	decimal	mm
cimt_2	Common carotid intima-media thickness, calculated as the mean of four values: maximum of multiple thickness estimates from the left far wall, left near wall, right far wall, and right near wall.	decimal	mm
carotid_stenosis_1	Extent of narrowing of the carotid artery.	encoded		0=None || 1=1%-24% || 2=25%-49% || 3=50%-74% || 4=75%-99% || 5=100%
carotid_plaque_1	Presence or absence of carotid plaque.	encoded		0=Plaque not present || 1=Plaque present
height_baseline_1	Body height at baseline.	decimal	cm
current_smoker_baseline_1	Indicates whether subject currently smokes cigarettes.	encoded		0=Does not currently smoke cigarettes || 1=Currently smokes cigarettes
weight_baseline_1	Body weight at baseline.	decimal	kg
ever_smoker_baseline_1	Indicates whether subject ever regularly smoked cigarettes.	encoded		0=Never a cigarette smoker || 1=Current or former cigarette smoker
bmi_baseline_1	Body mass index calculated at baseline.	decimal	kg/m^2
hemoglobin_mcnc_bld_1	Measurement of mass per volume, or mass concentration (mcnc), of hemoglobin in the blood (bld).	decimal	g / dL = grams per deciliter
hematocrit_vfr_bld_1	Measurement of hematocrit, the fraction of volume (vfr) of blood (bld) that is composed of red blood cells.	decimal	% = percentage
rbc_ncnc_bld_1	Count by volume, or number concentration (ncnc), of red blood cells in the blood (bld).	decimal	millions / microliter
wbc_ncnc_bld_1	Count by volume, or number concentration (ncnc), of white blood cells in the blood (bld).	decimal	thousands / microliter
basophil_ncnc_bld_1	Count by volume, or number concentration (ncnc), of basophils in the blood (bld).	decimal	thousands / microliter
eosinophil_ncnc_bld_1	Count by volume, or number concentration (ncnc), of eosinophils in the blood (bld).	decimal	thousands / microliter
neutrophil_ncnc_bld_1	Count by volume, or number concentration (ncnc), of neutrophils in the blood (bld).	decimal	thousands / microliter
lymphocyte_ncnc_bld_1	Count by volume, or number concentration (ncnc), of lymphocytes in the blood (bld).	decimal	thousands / microliter
monocyte_ncnc_bld_1	Count by volume, or number concentration (ncnc), of monocytes in the blood (bld).	decimal	thousands / microliter
platelet_ncnc_bld_1	Count by volume, or number concentration (ncnc), of platelets in the blood (bld).	integer	thousands / microliter
mch_entmass_rbc_1	Measurement of the average mass (entmass) of hemoglobin per red blood cell(rbc), known as mean corpuscular hemoglobin (MCH).	decimal	pg = picogram
mchc_mcnc_rbc_1	Measurement of the mass concentration (mcnc) of hemoglobin in a given volume of packed red blood cells (rbc), known as mean corpuscular hemoglobin concentration (MCHC).	decimal	g /dL = grams per deciliter
mcv_entvol_rbc_1	Measurement of the average volume (entvol) of red blood cells (rbc), known as mean corpuscular volume (MCV).	decimal	fL = femtoliter
pmv_entvol_bld_1	Measurement of the mean volume (entvol) of platelets in the blood (bld), known as mean platelet volume (MPV or PMV).	decimal	fL = femtoliter
rdw_ratio_rbc_1	Measurement of the ratio of variation in width to the mean width of the red blood cell (rbc) volume distribution curve taken at +/- 1 CV, known as red cell distribution width (RDW).	decimal	% = percentage
bp_systolic_1	Resting systolic blood pressure from the upper arm in a clinical setting.	decimal	mmHg
bp_diastolic_1	Resting diastolic blood pressure from the upper arm in a clinical setting.	decimal	mmHg
antihypertensive_meds_1	Indicator for use of antihypertensive medication at the time of blood pressure measurement.	encoded		0=Not taking antihypertensive medication || 1=Taking antihypertensive medication
race_1	Harmonized race category of participant.	encoded		AI_AN=American Indian_Alaskan Native or Native American || Asian=Asian || Black=Black or African American || HI_PI=Native Hawaiian or other Pacific Islander || Multiple=More than one race || Other=Other race || White=White or Caucasian
ethnicity_1	Indicator of Hispanic or Latino ethnicity.	encoded		both=ethnicity component dbGaP variable values for a subject were inconsistent/contradictory (e.g. over multiple visits) || HL=Hispanic or Latino || notHL=not Hispanic or Latino
hispanic_subgroup_1	classification of Hispanic/Latino background for Hispanic/Latino subjects where country or region of origin information is available	encoded		CentralAmerican=Central American || CostaRican=from Costa Rica || Cuban=Cuban || Dominican=Dominican || Mexican=Mexican || PuertoRican=Puerto Rican || SouthAmerican=South American
annotated_sex_1	Subject sex, as recorded by the study.	encoded		female=Female || male=Male
geographic_site_1	Recruitment/field center, baseline clinic, or geographic region.	encoded
subcohort_1	A distinct subgroup within a study, generally indicating subjects who share similar characteristics due to study design. Subjects may belong to only one subcohort.	encoded
lipid_lowering_medication_1	Indicates whether participant was taking any lipid-lowering medication at blood draw to measure lipids phenotypes	encoded		0=Participant was not taking lipid-lowering medication || 1=Participant was taking lipid-lowering medication
fasting_lipids_1	Indicates whether participant fasted for at least eight hours prior to blood draw to measure lipids phenotypes.	encoded		0=Participant did not fast_or fasted for fewer than eight hours prior to measurement of lipids phenotypes. || 1=Participant fasted for at least eight hours prior to measurement of lipids phenotypes
total_cholesterol_1	Blood mass concentration of total cholesterol	decimal	mg/dL
triglycerides_1	Blood mass concentration of triglycerides	decimal	mg/dL
hdl_1	Blood mass concentration of high-density lipoprotein cholesterol	decimal	mg/dL
ldl_1	Blood mass concentration of low-density lipoprotein cholesterol	decimal	mg/dL
vte_prior_history_1	An indicator of whether a subject had a venous thromboembolism (VTE) event prior to the start of the medical review process (including self-reported events).	encoded		0=did not have prior VTE event || 1=had prior VTE event
vte_case_status_1	An indicator of whether a subject experienced a venous thromboembolism event (VTE) that was verified by adjudication or by medical professionals.	encoded		0=Not known to ever have a VTE event_either self-reported or from medical records || 1=Experienced a VTE event as verified by adjudication or by medical professionals
age_at_*	For each phenotypic value for a given subject, an associated age at measurement is provided.	decimal	years	See TOPMed Harmonization Strategies for more information.
unit_*	For each harmonized variable, a paired “unit_variable” is provided, whose value indicates where in the documentation to look to find the set of component variables and the algorithm used to harmonize those variables.	encoded		See TOPMed Harmonization Strategies for more information.