Appendix 2: Table of TOPMed DCC Harmonized Variables in PIC-SURE
cac_volume_1
Coronary artery calcium volume using CT scan(s) of coronary arteries
decimal
cubic millimeters
cac_score_1
Coronary artery calcification (CAC) score using Agatston scoring of CT scan(s) of coronary arteries
decimal
cimt_1
Common carotid intima-media thickness, calculated as the mean of two values: mean of multiple thickness estimates from the left far wall and from the right far wall.
decimal
mm
cimt_2
Common carotid intima-media thickness, calculated as the mean of four values: maximum of multiple thickness estimates from the left far wall, left near wall, right far wall, and right near wall.
decimal
mm
carotid_stenosis_1
Extent of narrowing of the carotid artery.
encoded
0=None || 1=1%-24% || 2=25%-49% || 3=50%-74% || 4=75%-99% || 5=100%
carotid_plaque_1
Presence or absence of carotid plaque.
encoded
0=Plaque not present || 1=Plaque present
height_baseline_1
Body height at baseline.
decimal
cm
current_smoker_baseline_1
Indicates whether subject currently smokes cigarettes.
encoded
0=Does not currently smoke cigarettes || 1=Currently smokes cigarettes
weight_baseline_1
Body weight at baseline.
decimal
kg
ever_smoker_baseline_1
Indicates whether subject ever regularly smoked cigarettes.
encoded
0=Never a cigarette smoker || 1=Current or former cigarette smoker
bmi_baseline_1
Body mass index calculated at baseline.
decimal
kg/m^2
hemoglobin_mcnc_bld_1
Measurement of mass per volume, or mass concentration (mcnc), of hemoglobin in the blood (bld).
decimal
g / dL = grams per deciliter
hematocrit_vfr_bld_1
Measurement of hematocrit, the fraction of volume (vfr) of blood (bld) that is composed of red blood cells.
decimal
% = percentage
rbc_ncnc_bld_1
Count by volume, or number concentration (ncnc), of red blood cells in the blood (bld).
decimal
millions / microliter
wbc_ncnc_bld_1
Count by volume, or number concentration (ncnc), of white blood cells in the blood (bld).
decimal
thousands / microliter
basophil_ncnc_bld_1
Count by volume, or number concentration (ncnc), of basophils in the blood (bld).
decimal
thousands / microliter
eosinophil_ncnc_bld_1
Count by volume, or number concentration (ncnc), of eosinophils in the blood (bld).
decimal
thousands / microliter
neutrophil_ncnc_bld_1
Count by volume, or number concentration (ncnc), of neutrophils in the blood (bld).
decimal
thousands / microliter
lymphocyte_ncnc_bld_1
Count by volume, or number concentration (ncnc), of lymphocytes in the blood (bld).
decimal
thousands / microliter
monocyte_ncnc_bld_1
Count by volume, or number concentration (ncnc), of monocytes in the blood (bld).
decimal
thousands / microliter
platelet_ncnc_bld_1
Count by volume, or number concentration (ncnc), of platelets in the blood (bld).
integer
thousands / microliter
mch_entmass_rbc_1
Measurement of the average mass (entmass) of hemoglobin per red blood cell(rbc), known as mean corpuscular hemoglobin (MCH).
decimal
pg = picogram
mchc_mcnc_rbc_1
Measurement of the mass concentration (mcnc) of hemoglobin in a given volume of packed red blood cells (rbc), known as mean corpuscular hemoglobin concentration (MCHC).
decimal
g /dL = grams per deciliter
mcv_entvol_rbc_1
Measurement of the average volume (entvol) of red blood cells (rbc), known as mean corpuscular volume (MCV).
decimal
fL = femtoliter
pmv_entvol_bld_1
Measurement of the mean volume (entvol) of platelets in the blood (bld), known as mean platelet volume (MPV or PMV).
decimal
fL = femtoliter
rdw_ratio_rbc_1
Measurement of the ratio of variation in width to the mean width of the red blood cell (rbc) volume distribution curve taken at +/- 1 CV, known as red cell distribution width (RDW).
decimal
% = percentage
bp_systolic_1
Resting systolic blood pressure from the upper arm in a clinical setting.
decimal
mmHg
bp_diastolic_1
Resting diastolic blood pressure from the upper arm in a clinical setting.
decimal
mmHg
antihypertensive_meds_1
Indicator for use of antihypertensive medication at the time of blood pressure measurement.
encoded
0=Not taking antihypertensive medication || 1=Taking antihypertensive medication
race_1
Harmonized race category of participant.
encoded
AI_AN=American Indian_Alaskan Native or Native American || Asian=Asian || Black=Black or African American || HI_PI=Native Hawaiian or other Pacific Islander || Multiple=More than one race || Other=Other race || White=White or Caucasian
ethnicity_1
Indicator of Hispanic or Latino ethnicity.
encoded
both=ethnicity component dbGaP variable values for a subject were inconsistent/contradictory (e.g. over multiple visits) || HL=Hispanic or Latino || notHL=not Hispanic or Latino
hispanic_subgroup_1
classification of Hispanic/Latino background for Hispanic/Latino subjects where country or region of origin information is available
encoded
CentralAmerican=Central American || CostaRican=from Costa Rica || Cuban=Cuban || Dominican=Dominican || Mexican=Mexican || PuertoRican=Puerto Rican || SouthAmerican=South American
annotated_sex_1
Subject sex, as recorded by the study.
encoded
female=Female || male=Male
geographic_site_1
Recruitment/field center, baseline clinic, or geographic region.
encoded
subcohort_1
A distinct subgroup within a study, generally indicating subjects who share similar characteristics due to study design. Subjects may belong to only one subcohort.
encoded
lipid_lowering_medication_1
Indicates whether participant was taking any lipid-lowering medication at blood draw to measure lipids phenotypes
encoded
0=Participant was not taking lipid-lowering medication || 1=Participant was taking lipid-lowering medication
fasting_lipids_1
Indicates whether participant fasted for at least eight hours prior to blood draw to measure lipids phenotypes.
encoded
0=Participant did not fast_or fasted for fewer than eight hours prior to measurement of lipids phenotypes. || 1=Participant fasted for at least eight hours prior to measurement of lipids phenotypes
total_cholesterol_1
Blood mass concentration of total cholesterol
decimal
mg/dL
triglycerides_1
Blood mass concentration of triglycerides
decimal
mg/dL
hdl_1
Blood mass concentration of high-density lipoprotein cholesterol
decimal
mg/dL
ldl_1
Blood mass concentration of low-density lipoprotein cholesterol
decimal
mg/dL
vte_prior_history_1
An indicator of whether a subject had a venous thromboembolism (VTE) event prior to the start of the medical review process (including self-reported events).
encoded
0=did not have prior VTE event || 1=had prior VTE event
vte_case_status_1
An indicator of whether a subject experienced a venous thromboembolism event (VTE) that was verified by adjudication or by medical professionals.
encoded
0=Not known to ever have a VTE event_either self-reported or from medical records || 1=Experienced a VTE event as verified by adjudication or by medical professionals
age_at_*
For each phenotypic value for a given subject, an associated age at measurement is provided.
decimal
years
unit_*
For each harmonized variable, a paired “unit_variable” is provided, whose value indicates where in the documentation to look to find the set of component variables and the algorithm used to harmonize those variables.
encoded
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